EDNRB and GRK6

Data Source:
HPRD (in vitro)

		EDNRB	GRK6
Description		endothelin receptor type B	G protein-coupled receptor kinase 6
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Nuclear Membrane Membrane Raft	Plasma Membrane Membrane
	Molecular Function	Endothelin Receptor Activity Protein Binding Peptide Hormone Binding Type 1 Angiotensin Receptor Binding	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of PH Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Peripheral Nervous System Development Posterior Midgut Development Aging Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Maturation Response To Organic Cyclic Compound Vein Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling CGMP-mediated Signaling Melanocyte Differentiation Regulation Of Fever Generation Negative Regulation Of Cellular Protein Metabolic Process Enteric Smooth Muscle Cell Differentiation Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Epithelial Fluid Transport Vasoconstriction Vasodilation Negative Regulation Of Apoptotic Process Macrophage Chemotaxis Response To Pain Enteric Nervous System Development Regulation Of Epithelial Cell Proliferation Regulation Of Sensory Perception Of Pain Positive Regulation Of Penile Erection Cellular Response To Lipopolysaccharide Endothelin Receptor Signaling Pathway Response To Endothelin	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	G alpha (s) signalling events
Drugs		Bosentan IRL-1620 Sitaxentan Ambrisentan Enrasentan Tezosentan Macitentan
Diseases		Hirschsprung disease (HD) ABCD syndrome Nasopharyngeal cancer Waardenburg syndrome (WS)
GWAS		Craniofacial microsomia ( 26853712) Hair color ( 23548203 29662168) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: CAV1 EDN1 EDN3 GNA11 GNA13 GRK6 NOS3	19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R
Entrez ID		1910	2870
HPRD ID		08834	02925
Ensembl ID		ENSG00000136160	ENSG00000198055
Uniprot IDs		A0A024R638 A0A024R645 P24530	B3KPS5 P43250
PDB IDs		5GLH 5GLI 5X93 5XPR 6IGK 6IGL 6LRY	2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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