GRK6 and SNCB

Data Source:
BioGRID (enzymatic study)

		GRK6	SNCB
Description		G protein-coupled receptor kinase 6	synuclein beta
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Cytosol Inclusion Body Neuronal Cell Body Axon Terminus
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Transition Metal Ion Binding Cuprous Ion Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	Chemical Synaptic Transmission Response To Metal Ion Dopamine Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Neuron Death
Pathways		G alpha (s) signalling events	MTF1 activates gene expression
Drugs
Diseases			Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	13 interacting genes: AKT1 APP CENPT GRK1 GRK5 GRK6 HSPA1A LNX1 MORN4 PLK1 PLK3 SEPTIN4 SNCA
Entrez ID		2870	6620
HPRD ID		02925	03980
Ensembl ID		ENSG00000198055	ENSG00000074317
Uniprot IDs		B3KPS5 P43250	G4Y815 G4Y816 Q16143
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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