E2F2 and CD48

Data Source:
BioGRID (affinity chromatography technology)

		E2F2	CD48
Description		E2F transcription factor 2	CD48 molecule
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GO Annotations	Cellular Component	Chromatin Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Antigen Binding Protein Binding Signaling Receptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process	Regulation Of Adaptive Immune Response Defense Response Leukocyte Migration
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence CDC6 association with the ORC:origin complex Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		19 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1	10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK
Entrez ID		1870	962
HPRD ID		02692	00177
Ensembl ID		ENSG00000007968	ENSG00000117091
Uniprot IDs		Q14209	A0A087X1S7 P09326
PDB IDs		1N4M	2EDO
Enriched GO Terms of Interacting Partners?
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