E2F2 and ARID3A

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		E2F2	ARID3A
Description		E2F transcription factor 2	AT-rich interaction domain 3A
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GO Annotations	Cellular Component	Chromatin Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytosol Membrane Raft
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Sprouting Angiogenesis Lens Fiber Cell Apoptotic Process	Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Oxidative Stress Induced Senescence Oncogene Induced Senescence CDC6 association with the ORC:origin complex Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 27863252)	High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio ( 20548946)
Interacting Genes		19 interacting genes: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 GRB2 KMT5A RB1 RNF144A RYBP SP1 SPIB TFDP1 TFDP2 UCHL5 YY1	21 interacting genes: ANKRD11 APP BTK DSP E2F1 E2F2 E2F4 KRT31 MAGEB2 MAGEB4 MORF4L1 MORF4L2 NOTCH2NLA PML REP15 SP100 TIMM8A TP53 TTC32 UBE2E3 XPA
Entrez ID		1870	1820
HPRD ID		02692	10343
Ensembl ID		ENSG00000007968	ENSG00000116017
Uniprot IDs		Q14209	Q99856
PDB IDs		1N4M	2KK0 4LJX
Enriched GO Terms of Interacting Partners?
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