CD48 and IL18R1

Data Source:
HPRD (in vivo, in vitro)

		CD48	IL18R1
Description		CD48 molecule	interleukin 18 receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Anchored Component Of Membrane Intrinsic Component Of Plasma Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Interleukin-18 Receptor Complex
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity	Interleukin-1 Receptor Activity Protein Binding Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Adaptive Immune Response Defense Response Leukocyte Migration	Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Cell surface interactions at the vascular wall	Interleukin-37 signaling Interleukin-18 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Multiple sclerosis ( 31604244) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Asthma ( 23028483 31361310 31959851 30929738 20860503 31619474 26620591 29273806 22561531) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738 29273806) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23042114 26482879) Atypical femoral fracture in phosphonate treatment ( 31006051) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488 28240269) Celiac disease ( 20190752 18311140) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Delirium ( 29631748) Eczema ( 31361310) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 28067908 23128233) Leprosy ( 25642632) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		10 interacting genes: BRIX1 CD2 CD244 CD247 EEF1D FYN GNAI3 IL18R1 IL18RAP LCK	4 interacting genes: CD48 IL18 IL1RAP IL37
Entrez ID		962	8809
HPRD ID		00177	05138
Ensembl ID		ENSG00000117091	ENSG00000115604
Uniprot IDs		A0A087X1S7 P09326	Q13478
PDB IDs		2EDO	3WO3 3WO4 4R6U
Enriched GO Terms of Interacting Partners?
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