DVL2 and CARD9

Data Source:
BioGRID (two hybrid)

		DVL2	CARD9
Description		dishevelled segment polarity protein 2	caspase recruitment domain family member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome Lateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Protein Self-association	Protein Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Segment Specification Heart Development Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Organization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Beta-catenin Destruction Complex Disassembly	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Metabolite levels ( 31628463) Metabolite levels (small molecules and protein measures) ( 27005778)	Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		103 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 KLHL12 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UBE2D3 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581	138 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CABP2 CARD10 CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DISC1 DUSP13 DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GAS8 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TEX33 TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3
Entrez ID		1856	64170
HPRD ID		03690	06236
Ensembl ID		ENSG00000004975	ENSG00000187796
Uniprot IDs		O14641	A0A024R8F1 Q9H257
PDB IDs		2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK	6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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