CARD9 and KRTAP10-5

Data Source:
BioGRID (two hybrid)

		CARD9	KRTAP10-5
Description		caspase recruitment domain family member 9	keratin associated protein 10-5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex	Cytosol Keratin Filament
	Molecular Function	Protein Binding Protein Homodimerization Activity CARD Domain Binding	Protein Binding Identical Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Response To Fungus Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Response To Drug Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Defense Response To Virus	Keratinization
Pathways		NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		138 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CABP2 CARD10 CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DISC1 DUSP13 DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GAS8 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TEX33 TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3	143 interacting genes: ADAMTSL4 AEN ALDH3B1 AMOTL2 BCL6B BMP7 BYSL C11orf87 C17orf50 CARD9 CATSPER1 CHRD CNNM3 CREB5 CYSRT1 DHX57 ECE1 EIF4E2 ENKD1 FAM74A4 FAM76B FARS2 FBXO34 FCHO1 GATA1 GLIDR GLRX3 GNE GOLGA8EP GPRIN2 HHEX HOXA1 HPCAL1 KRTAP1-3 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP13-1 KRTAP13-2 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1B LCE1C LCE1D LCE1E LCE2A LCE2C LCE2D LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LIMS2 LUZP4 MEOX2 MOBP MT1DP MXI1 NAA10 NBPF19 NECTIN2 NOTCH2NLA NPDC1 NR4A1 NR4A3 NTAQ1 NUFIP2 OTX1 POM121L8P POU4F2 PRKAB2 PRKAG1 PRR13 RBP3 SCNM1 SHFL SLC23A1 SLC6A20 SMCP SPACA9 SPATA3 SPRY1 SPRY2 STK16 TBC1D16 THAP10 TNP2 TNS2 TRIM42 TRPV6 TULP3 TXNDC5 TYMSOS UTP23 WT1 WT1-AS YY1 ZBTB24 ZBTB48 ZFYVE21 ZNF124 ZNF20 ZNF264 ZNF273 ZNF286A ZNF32 ZNF320 ZNF329 ZNF34 ZNF417 ZNF433 ZNF439 ZNF440 ZNF559 ZNF572 ZNF578 ZNF587 ZNF670 ZNF679 ZNF696 ZNF697 ZNF707 ZNF785 ZNF792 ZSCAN21 ZSCAN26
Entrez ID		64170	386680
HPRD ID		06236	11191
Ensembl ID		ENSG00000187796	ENSG00000241123
Uniprot IDs		A0A024R8F1 Q9H257
PDB IDs		6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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