DTX1 and UBE2U

Data Source:
BioGRID (two hybrid)

		DTX1	UBE2U
Description		deltex E3 ubiquitin ligase 1	ubiquitin conjugating enzyme E2 U
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body	HULC Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Transcription, DNA-templated Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Cellular Response To Leukemia Inhibitory Factor	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Visceral adipose tissue adjusted for BMI ( 22589738)	Severe bacterial meningitis ( 31092817)
Interacting Genes		21 interacting genes: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 PRKAR1A TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	68 interacting genes: ANAPC11 BARD1 BFAR CADPS2 CBL CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 UBA1 VPS11 VPS41 ZSWIM2
Entrez ID		1840	148581
HPRD ID		03991	14599
Ensembl ID		ENSG00000135144	ENSG00000177414
Uniprot IDs		Q86Y01	A0A140VJY9 Q5VVX9
PDB IDs		6Y5N 6Y5P	1YRV
Enriched GO Terms of Interacting Partners?
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