DSC2 and DSG1

Data Source:
HPRD (in vivo)

		DSC2	DSG1
Description		desmocollin 2	desmoglein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Integral Component Of Membrane Desmosome Cytoplasmic Vesicle Extracellular Exosome	Cornified Envelope Cytosol Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Desmosome Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication	Calcium Ion Binding Protein Binding Toxic Substance Binding Gamma-catenin Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cellular Response To Starvation Keratinization Cornification Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential	Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Keratinization Response To Progesterone Neutrophil Degranulation Protein Stabilization Maternal Process Involved In Female Pregnancy Cornification Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases		Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Striate palmoplantar keratoderma
GWAS		Blood protein levels ( 30072576 29875488) Bronchopulmonary dysplasia ( 23897914) Metabolite levels ( 23823483)	Eosinophilic esophagitis (pediatric) ( 20208534) perceptual and visual search speed (trail making test A) (age interaction) ( 24629169) Yeast infection ( 28928442)
Interacting Genes		6 interacting genes: CLK1 DSG1 DSG2 JUP PKP2 PKP3	8 interacting genes: CDC42 DSC1 DSC2 JUP KLK5 PKP1 PKP2 PKP3
Entrez ID		1824	1828
HPRD ID		00512	00515
Ensembl ID		ENSG00000134755	ENSG00000134760
Uniprot IDs		A0A3B3ISU0 Q02487	Q02413
PDB IDs		5ERP 5J5J
Enriched GO Terms of Interacting Partners?
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