DYNC1LI2 and HPR

Data Source:
BioGRID (biochemical)

		DYNC1LI2	HPR
Description		dynein cytoplasmic 1 light intermediate chain 2	haptoglobin-related protein
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Lysosome Late Endosome Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane	Extracellular Region Extracellular Space Spherical High-density Lipoprotein Particle Extracellular Exosome Blood Microparticle
	Molecular Function	Motor Activity ATP Binding Identical Protein Binding Dynein Heavy Chain Binding	Serine-type Endopeptidase Activity Hemoglobin Binding
	Biological Process	Microtubule Cytoskeleton Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus	Acute Inflammatory Response Receptor-mediated Endocytosis Positive Regulation Of Cell Death Zymogen Activation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Scavenging of heme from plasma
Drugs			Zinc Copper Zinc acetate
Diseases
GWAS		Lipid traits ( 30576415)	Blood protein levels ( 28240269) Cholesterol, total ( 24097068 28270201 25961943 20686565 26582766) Coronary artery disease ( 32469254 33020668) Hematocrit ( 32888494) LDL cholesterol ( 24097068 25961943 20686565 26582766) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		4 interacting genes: APP BRCA2 DMTN GAA	3 interacting genes: APOA1 IGHM VKORC1
Entrez ID		1783	3250
HPRD ID		09923	00773
Ensembl ID		ENSG00000135720	ENSG00000261701
Uniprot IDs		A0A024R6Z0 O43237 Q63HJ8	P00739
PDB IDs		6F1T 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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