DLG3 and CRIPT

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DLG3	CRIPT
Description		discs large MAGUK scaffold protein 3	CXXC repeat containing interactor of PDZ3 domain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Ionotropic Glutamate Receptor Complex Basolateral Plasma Membrane Cell Junction	Cytoplasm Postsynaptic Density Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft
	Molecular Function	Protein Binding Kinase Binding Phosphatase Binding	Protein Binding Microtubule Binding PDZ Domain Binding Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	MAPK Cascade Negative Regulation Of Cell Population Proliferation Embryo Development Negative Regulation Of Phosphatase Activity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Tyrosine Kinase Activity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of NMDA Receptor Activity	Cytoplasmic Microtubule Organization Protein Localization To Microtubule Establishment Of Protein Localization Regulation Of Postsynaptic Density Protein 95 Clustering
Pathways		Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Non-syndromic X-linked mental retardation
GWAS		Mean platelet volume ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20966902) Pulse pressure (alcohol consumption interaction) ( 24376456) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		48 interacting genes: ABCA1 ADGRL1 APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OSBP2 PLEKHA2 PTK2B RPS8 SCN4A SCN5A SEMA4C SYNGAP1 VTN	7 interacting genes: DLG1 DLG2 DLG3 DLG4 PATJ TUBB UBQLN4
Entrez ID		1741	9419
HPRD ID		02177	05208
Ensembl ID		ENSG00000082458	ENSG00000119878
Uniprot IDs		Q59FY1 Q92796	Q9P021
PDB IDs		1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?
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