DKC1 and LYPLA2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DKC1	LYPLA2
Description		dyskerin pseudouridine synthase 1	lysophospholipase 2
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex	Cytoplasm Golgi Stack Cytosol Extracellular Exosome
	Molecular Function	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding	Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Cadherin Binding Carboxylic Ester Hydrolase Activity
	Biological Process	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA RNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis	Protein Depalmitoylation Fatty Acid Metabolic Process Axon Guidance Protein Phosphopantetheinylation Acylglycerol Catabolic Process Prostaglandin Catabolic Process
Pathways		Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol	L1CAM interactions
Drugs
Diseases		Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS
Interacting Genes		10 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SSR1 TERC	5 interacting genes: APP DKC1 INCA1 MED31 SCMH1
Entrez ID		1736	11313
HPRD ID		02129	07127
Ensembl ID		ENSG00000130826	ENSG00000011009
Uniprot IDs		O60832	A0A140VJC9 O95372
PDB IDs			5SYN 6BJE
Enriched GO Terms of Interacting Partners?
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