NQO1 and DNAJB1

Data Source:
HPRD (in vitro, in vivo)

		NQO1	DNAJB1
Description		NAD(P)H quinone dehydrogenase 1	DnaJ heat shock protein family (Hsp40) member B1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Dendrite Neuronal Cell Body Synapse	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse
	Molecular Function	RNA Binding NAD(P)H Dehydrogenase (quinone) Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Superoxide Dismutase Activity Protein Binding Identical Protein Binding	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding
	Biological Process	Response To Ischemia NADH Oxidation Regulation Of Cellular Amino Acid Metabolic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Oxidative Stress Synaptic Transmission, Cholinergic Aging Response To Nutrient Response To Toxic Substance Response To Hormone Response To Carbohydrate Response To Amine Removal Of Superoxide Radicals Response To Estradiol Response To Testosterone Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Response To Ethanol Response To Electrical Stimulus Cellular Response To Hydrogen Peroxide NADPH Oxidation Cellular Response To Metal Ion Response To Tetrachloromethane Response To L-glutamine Response To Hydrogen Sulfide Response To Flavonoid	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat
Pathways		Regulation of ornithine decarboxylase (ODC)	Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling
Drugs		Menadione Dicoumarol Duroquinone 3-Hydroxymethyl-5-Aziridinyl-1methyl-2-[1h-Indole-4,7-Dione]-Propanol ES-936 Cibacron Blue Flavin adenine dinucleotide 5-Methoxy-1,2-Dimethyl-3-(Phenoxymethyl)Indole-4,7-Dione RH-1 Bishydroxy[2h-1-Benzopyran-2-One,1,2-Benzopyrone] 3-(HYDROXYMETHYL)-1-METHYL-5-(2-METHYLAZIRIDIN-1-YL)-2-PHENYL-1H-INDOLE-4,7-DIONE Cannabidiol
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Blood osmolality (transformed sodium) ( 28360221) Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31015462) Mean platelet volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Risk-taking tendency (4-domain principal component model) ( 30643258) Triglyceride levels ( 32203549)	Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)
Interacting Genes		9 interacting genes: CDC42 DNAJB1 GALT HIF1A HSPA1A ING1 STUB1 TP53 UBE2D1	33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 TTLL12 ZFP36
Entrez ID		1728	3337
HPRD ID		00518	05198
Ensembl ID		ENSG00000181019	ENSG00000132002
Uniprot IDs		B4DLR8 P15559	P25685 Q6FHS4
PDB IDs		1D4A 1DXO 1GG5 1H66 1H69 1KBO 1KBQ 1QBG 2F1O 3JSX 4CET 4CF6 5A4K 5EA2 5EAI 5FUQ 6FY4	1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR
Enriched GO Terms of Interacting Partners?
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