DNAJB1 and GLB1

Data Source:
HPRD (in vitro)

		DNAJB1	GLB1
Description		DnaJ heat shock protein family (Hsp40) member B1	galactosidase beta 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Postsynaptic Density Neuronal Cell Body Dendritic Spine Sperm Head Extracellular Exosome Glutamatergic Synapse	Extracellular Region Cytoplasm Vacuole Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	ATPase Activator Activity Transcription Corepressor Activity Protein Binding Hsp70 Protein Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding ATPase Binding	Beta-galactosidase Activity Protein Binding Galactoside Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Forebrain Development Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Cellular Response To Heat	Glycosaminoglycan Catabolic Process Glycosphingolipid Metabolic Process Galactose Catabolic Process Keratan Sulfate Catabolic Process Neutrophil Degranulation Cellular Carbohydrate Metabolic Process Response To Cortisone Response To Thyroglobulin Triiodothyronine
Pathways		Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation MAPK6/MAPK4 signaling	Glycosphingolipid metabolism Keratan sulfate degradation HS-GAG degradation MPS IV - Morquio syndrome B Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs			Lactose
Diseases			Galactosialidosis GM1 gangliosidosis Mucopolysaccharidosis type IV (MPS4), including: Morquio syndrome A (MPS4A); Morquio syndrome B (MPS4B)
GWAS		Adventurousness ( 30643258) General risk tolerance (MTAG) ( 30643258)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Atopic dermatitis ( 23042114) Celiac disease ( 22057235) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hepatocellular carcinoma ( 21105107) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		33 interacting genes: A2M AKT1 ANK2 APP BDKRB1 BRCA1 BRMS1 CENPE CYP2C8 DNAJA2 DNAJC3 ECSIT FANCA FANCC GLB1 HSF1 HSPA1A HSPA4 HSPA8 MAST1 NQO1 NRAS PEA15 PLEKHO1 PSEN2 PTGES3 SOD1 SPP1 STUB1 TERF1 TP53 TTLL12 ZFP36	11 interacting genes: CSNK2B CTSA DNAJB1 FOS GOLM1 NEU1 PLK1 SLC10A6 SLC30A2 SLC7A1 TK1
Entrez ID		3337	2720
HPRD ID		05198	01975
Ensembl ID		ENSG00000132002	ENSG00000170266
Uniprot IDs		P25685 Q6FHS4	B7Z6Q5 P16278
PDB IDs		1HDJ 2QLD 3AGX 3AGY 3AGZ 4WB7 6BYR	3THC 3THD 3WEZ 3WF0 3WF1 3WF2 3WF3 3WF4
Enriched GO Terms of Interacting Partners?
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