GSDME and TIFA

Data Source:
BioGRID (two hybrid)

		GSDME	TIFA
Description		gasdermin E	TRAF interacting protein with forkhead associated domain
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane	Cytoplasm
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cardiolipin Binding	Protein Binding
	Biological Process	Sensory Perception Of Sound Cell Death Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Inner Ear Receptor Cell Differentiation Necrotic Cell Death Pyroptosis Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cytoplasmic Pattern Recognition Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Homooligomerization
Pathways			Alpha-protein kinase 1 signaling pathway
Drugs
Diseases		Deafness, autosomal dominant
GWAS			Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		3 interacting genes: ITGB1BP1 PTN TIFA	23 interacting genes: AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2
Entrez ID		1687	92610
HPRD ID		02996	09835
Ensembl ID		ENSG00000105928	ENSG00000145365
Uniprot IDs		A0A024RA58 A4FVA8 O60443	Q96CG3
PDB IDs			4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?
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