DCN and COL4A3

Data Source:
HPRD (in vivo)

		DCN	COL4A3
Description		decorin	collagen type IV alpha 3 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VI Trimer Extracellular Space Golgi Lumen Lysosomal Lumen Collagen-containing Extracellular Matrix	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix
	Molecular Function	RNA Binding Protein Binding Collagen Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein N-terminus Binding Extracellular Matrix Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Kidney Development Placenta Development Skeletal Muscle Tissue Development Aging Response To Mechanical Stimulus Animal Organ Morphogenesis Positive Regulation Of Autophagy Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Macroautophagy Negative Regulation Of Angiogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Fission Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Blood Circulation Negative Regulation Of Cell Population Proliferation Response To Glucose Negative Regulation Of Endopeptidase Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Degradation of the extracellular matrix A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases		Congenital stromal corneal dystrophy (CSCD); Congenital hereditary stromal dystrophy; Witschel dystrophy	Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 32528159 29760442) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998) Refractive error ( 32231278) Sudden cardiac arrest ( 21658281)	Advanced age-related macular degeneration ( 26691988) Central corneal thickness ( 32528159 31798171 29760442) Corneal structure ( 23291589) Diabetic nephropathy in type 1 diabetes ( 31537649) Hematuria ( 30476138) Hematuria (moderate to severe) ( 30476138) Intraocular pressure ( 29235454) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649) Macroalbuminuria in type 1 diabetes ( 31537649) Macular thickness ( 30535121) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Refractive error ( 32231278) Resting heart rate ( 27798624)
Interacting Genes		30 interacting genes: AHSG BRCA1 C1QA CCN4 COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		1634	1285
HPRD ID		00501	00354
Ensembl ID		ENSG00000011465	ENSG00000169031
Uniprot IDs		A0A024RBG6 P07585 Q6FH10	Q01955
PDB IDs			5NB0
Enriched GO Terms of Interacting Partners?
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