ZFPM1 and GIPC1

Data Source:
HPRD (two hybrid)

		ZFPM1	GIPC1
Description		zinc finger protein, FOG family member 1	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Transcription Factor Binding Metal Ion Binding	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II T-helper Cell Lineage Commitment Outflow Tract Morphogenesis Atrioventricular Valve Morphogenesis Mitral Valve Formation Tricuspid Valve Formation Heart Development Blood Coagulation Regulation Of Definitive Erythrocyte Differentiation Cell Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Granulocyte Differentiation Negative Regulation Of Protein Binding Regulation Of Chemokine Production Negative Regulation Of Interleukin-4 Production Positive Regulation Of Interferon-gamma Production Embryonic Hemopoiesis Megakaryocyte Development Negative Regulation Of Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Morphogenesis Definitive Erythrocyte Differentiation Primitive Erythrocyte Differentiation Negative Regulation Of Mast Cell Differentiation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Transcriptional Activation By Promoter-enhancer Looping	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Calcium levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hair color ( 26926045) Hematocrit ( 32888494 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 29083408 32154731) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Platelet count ( 29403010 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) Testicular germ cell tumor ( 28604728 28604732 26503584) Vascular endothelial growth factor levels ( 26910538) White blood cell count (basophil) ( 29403010 27863252)	Kidney stones ( 31729369)
Interacting Genes		6 interacting genes: CTBP2 GATA1 GATA2 GIPC1 GSK3B TOP3B	36 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		161882	10755
HPRD ID		11800	05462
Ensembl ID		ENSG00000179588	ENSG00000123159
Uniprot IDs		Q8IX07	A0A024R7I0 A0A024R7I1 A8K2I7 O14908
PDB IDs		2XU7
Enriched GO Terms of Interacting Partners?
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