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GIPC1 and LHCGR
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
GIPC1
LHCGR
Description
GIPC PDZ domain containing family member 1
luteinizing hormone/choriogonadotropin receptor
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Brush Border
Cell Cortex
Synaptic Vesicle
Vesicle Membrane
Membrane
Endocytic Vesicle
Cytoplasmic Vesicle
Dendritic Spine
Dendritic Shaft
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Endosome
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
Actin Binding
Signaling Receptor Binding
Protein Binding
Myosin Binding
PDZ Domain Binding
Identical Protein Binding
Cadherin Binding
Luteinizing Hormone Receptor Activity
G Protein-coupled Peptide Receptor Activity
Choriogonadotropin Hormone Receptor Activity
Choriogonadotropin Hormone Binding
Biological Process
Protein Targeting
G Protein-coupled Receptor Signaling Pathway
Chemical Synaptic Transmission
Glutamate Secretion
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Stability
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cytokinesis
Endothelial Cell Migration
Positive Regulation Of Melanin Biosynthetic Process
Regulation Of Synaptic Plasticity
Cellular Response To Interleukin-7
Regulation Of Synaptic Vesicle Exocytosis
Ovarian Follicle Development
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Male Gonad Development
Hormone-mediated Signaling Pathway
Ovulation Cycle Process
Male Genitalia Development
Positive Regulation Of Inositol Trisphosphate Biosynthetic Process
Luteinizing Hormone Signaling Pathway
Cognition
Cellular Response To Gonadotropin Stimulus
Cellular Response To Luteinizing Hormone Stimulus
Pathways
Hormone ligand-binding receptors
G alpha (s) signalling events
ADORA2B mediated anti-inflammatory cytokines production
Drugs
Goserelin
Menotropins
Lutropin alfa
Cetrorelix
Choriogonadotropin alfa
Buserelin
Chorionic Gonadotropin (Human)
Diseases
46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
Premature ovarian failure
Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP)
GWAS
Kidney stones (
31729369
)
Body mass index (
28892062
)
Laterality in neovascular age-related macular degeneration (
28775256
)
Polycystic ovary syndrome (
22885925
21151128
)
Sex hormone-binding globulin levels (
22829776
)
Triglyceride levels (
32154731
)
Interacting Genes
36 interacting genes:
ACTN1
ADRB1
CARD10
CD93
DDIT3
DRD2
DRD3
FZD3
GSK3B
IGF1R
ITGA5
ITGA6
KIF1B
LHCGR
LPAR1
LPAR2
LRP1
LRP2
LRP8
MYO6
NRP1
NTRK1
NTRK2
PLEKHA2
RGS1
RGS19
SDC4
SEMA4B
SEMA4C
SH3BP4
SLC2A1
TGFBR3
TPBG
TYRP1
ZFPM1
ZNF408
11 interacting genes:
ARRB2
CANX
CGA
CGB3
CHST9
GIPC1
GNAI2
GNAS
LHB
SLC9A3R1
TSHR
Entrez ID
10755
3973
HPRD ID
05462
01073
Ensembl ID
ENSG00000123159
ENSG00000138039
Uniprot IDs
A0A024R7I0
A0A024R7I1
A8K2I7
O14908
P22888
PDB IDs
1LUT
1XUL
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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