DAB2 and MIB1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DAB2	MIB1
Description		DAB adaptor protein 2	MIB E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein C-terminus Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Integrin-mediated Signaling Pathway Multicellular Organism Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways		Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 29403010) Birth weight ( 31043758) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)	Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Severe progression in rheumatoid arthritis ( 29065906)
Interacting Genes		40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2	15 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W
Entrez ID		1601	57534
HPRD ID		03139	06660
Ensembl ID		ENSG00000153071	ENSG00000101752
Uniprot IDs		A0A024R036 B2RAW0 P98082	Q86YT6
PDB IDs		2LSW 6O5O 6OVF	4TSE 4XI6 4XI7 4XIB
Enriched GO Terms of Interacting Partners?
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