CYP2C9 and STAT5A

Data Source:
BioGRID (two hybrid)

		CYP2C9	STAT5A
Description		cytochrome P450 family 2 subfamily C member 9	signal transducer and activator of transcription 5A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleoplasm Cytosol
	Molecular Function	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen (S)-limonene 6-monooxygenase Activity (S)-limonene 7-monooxygenase Activity Heme Binding Caffeine Oxidase Activity (R)-limonene 6-monooxygenase Activity Aromatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Organic Acid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Urea Metabolic Process Monocarboxylic Acid Metabolic Process Drug Catabolic Process Exogenous Drug Catabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Amide Metabolic Process Icosanoid Biosynthetic Process Oxidative Demethylation Omega-hydroxylase P450 Pathway	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Lactation Cytokine-mediated Signaling Pathway Taurine Metabolic Process Interleukin-15-mediated Signaling Pathway Reelin-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Pathways		Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of maresin-like SPMs	Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Ferroheme C Diacerein Benzbromarone
Diseases
GWAS		Blood metabolite levels ( 24816252) Clopidogrel active metabolite levels ( 28207573) Dehydroepiandrosterone sulphate levels ( 21533175) Diastolic blood pressure ( 27841878) Immune response to smallpox vaccine (IL-6) ( 22542470) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Pulse pressure ( 27841878) Response to clopidogrel therapy ( 28207573 19706858) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Serum metabolite levels ( 23093944) Systolic blood pressure ( 27841878) Warfarin maintenance dose ( 18535201 23755828 20833655 19300499 26265036)	Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 27569725 28067908 23128233) Low density lipoprotein cholesterol levels ( 32154731) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: CDC37 CYP2D6 CYP3A4 ECSIT MAST1 POR RAB3D RNF32 STAMBP STAT5A	72 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FBXW7 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TET2 TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		1559	6776
HPRD ID		03084	03301
Ensembl ID		ENSG00000138109	ENSG00000126561
Uniprot IDs		P11712 S5RV20	A0A384N5W4 A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1OG2 1OG5 1R9O 4NZ2 5A5I 5A5J 5K7K 5W0C 5X23 5X24 5XXI 6VLT
Enriched GO Terms of Interacting Partners?
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