STAT5A and AQP11

Data Source:
BioGRID (two hybrid)

		STAT5A	AQP11
Description		signal transducer and activator of transcription 5A	aquaporin 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Integral Component Of Membrane Dendrite Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Water Channel Activity Glycerol Channel Activity Channel Activity Identical Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Lactation Cytokine-mediated Signaling Pathway Taurine Metabolic Process Interleukin-15-mediated Signaling Pathway Reelin-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Hormone Receptor Signaling Pathway Via JAK-STAT	Protein Targeting To Membrane Ion Transport Water Transport Positive Regulation Of Cell Population Proliferation Cellular Water Homeostasis Glycerol Transport Urea Transport Water Homeostasis Oxygen Homeostasis Protein Glycosylation In Endoplasmic Reticulum Endosomal Lumen Acidification Negative Regulation Of Epithelial Cell Proliferation Protein Homooligomerization Proximal Tubule Development Hydrogen Peroxide Transmembrane Transport Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of ERAD Pathway
Pathways		Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Growth hormone receptor signaling Growth hormone receptor signaling	Passive transport by Aquaporins
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 27569725 28067908 23128233) Low density lipoprotein cholesterol levels ( 32154731) Ulcerative colitis ( 28067908)	Tourette syndrome ( 30818990) Weight loss (gastric bypass surgery) ( 23643386)
Interacting Genes		72 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FBXW7 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TET2 TSLP TXNDC11 UGT2B4 WASH2P ZNF596	1 interacting genes: STAT5A
Entrez ID		6776	282679
HPRD ID		03301	16503
Ensembl ID		ENSG00000126561	ENSG00000178301
Uniprot IDs		A0A384N5W4 A8K6I5 K7EK35 P42229 Q59GY7	Q8NBQ7
PDB IDs
Enriched GO Terms of Interacting Partners?
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