RNF217 and HAX1

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		RNF217	HAX1
Description		ring finger protein 217	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Integral Component Of Membrane	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Rosacea symptom severity ( 29771307)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: HAX1	25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420
Entrez ID		154214	10456
HPRD ID		17125	12075
Ensembl ID		ENSG00000146373	ENSG00000143575
Uniprot IDs		B3KVC8 Q8TC41	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?