HAX1 and IL1A

Data Source:
HPRD (in vivo, in vitro)

		HAX1	IL1A
Description		HCLS1 associated protein X-1	interleukin 1 alpha
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nuclear Envelope Transcription Regulator Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Protein Binding Interleukin-1 Binding Protein N-terminus Binding	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Cellular Sodium Ion Homeostasis Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cell Division Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases		Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia	Graft-versus-host disease
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein level ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		25 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL YWHAQ ZNF420	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		10456	3552
HPRD ID		12075	00988
Ensembl ID		ENSG00000143575	ENSG00000115008
Uniprot IDs		A0A0S2Z565 A0A0S2Z591 O00165	P01583
PDB IDs			1ITA 2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?
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