SGO1 and PPP2CB

Data Source:
HPRD (in vivo)

		SGO1	PPP2CB
Description		shugoshin 1	protein phosphatase 2 catalytic subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleoplasm Centrosome Cytosol	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Cytosol
	Molecular Function	Protein Binding Kinase Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Tau Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Homologous Chromosome Segregation Meiotic Sister Chromatid Cohesion Cell Division Mitotic Sister Chromatid Cohesion, Centromeric	Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Peptidyl-serine Dephosphorylation Positive Regulation Of Microtubule Binding
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Integration of energy metabolism PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion CTLA4 inhibitory signaling Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation
Drugs			Vitamin E
Diseases
GWAS			Daytime sleep phenotypes ( 27126917)
Interacting Genes		20 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6	41 interacting genes: ACP5 AURKA AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B ZFP28 ZNF775
Entrez ID		151648	5516
HPRD ID		12377	01487
Ensembl ID		ENSG00000129810	ENSG00000104695
Uniprot IDs		A0A024R2J4 B5BUA4 Q5FBB7	A0A140VJS0 P62714
PDB IDs		3FGA 3Q6S 4A0I
Enriched GO Terms of Interacting Partners?
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