CTNNA1 and NANS

Data Source:
BioGRID (two hybrid)

		CTNNA1	NANS
Description		catenin alpha 1	N-acetylneuraminate synthase
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Flotillin Complex Lamellipodium Cell Junction Intracellular Membrane-bounded Organelle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding	N-acylneuraminate Cytidylyltransferase Activity N-acylneuraminate-9-phosphate Synthase Activity N-acetylneuraminate Synthase Activity
	Biological Process	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Cell Migration Axon Regeneration Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Apical Junction Assembly Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Cell-cell Adhesion Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	CMP-N-acetylneuraminate Biosynthetic Process Carbohydrate Biosynthetic Process Glycosylation
Pathways		Adherens junctions interactions VEGFR2 mediated vascular permeability Myogenesis Myogenesis RHO GTPases activate IQGAPs	Sialic acid metabolism
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Malaria ( 31844061) Schizophrenia ( 25056061)	Alopecia areata ( 25608926) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		52 interacting genes: ACTN1 AFDN AJUBA AKT1 ALDOB APC APP ARMC8 BAAT CA9 CCDC180 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CSNK2A1 CTBP1 CTNNB1 CTSV DLG1 F2RL1 FBP1 FBP2 FRAT2 HRAS HSD17B3 JUP LRATD2 MAP2K1 MTNR1A MTNR1B NANS OBI1 PKD1 PSEN1 SASH1 SFRP2 SFRP4 SMAD1 SPTAN1 SPTBN1 STX17 TDRD7 TJP1 TJP2 UBE2I VCL ZGPAT ZNF189 ZNF510	19 interacting genes: APC AURKA BCL10 BUB1 CDH1 CTNNA1 EGFR FBXO7 FBXW7 FLCN MCC MLH3 MSH6 ODC1 PDGFRL PTPRJ SRC STK11 TLR2
Entrez ID		1495	54187
HPRD ID		00285	07285
Ensembl ID		ENSG00000044115	ENSG00000095380
Uniprot IDs		A0A384MDY0 B4DKT9 B4DU00 G3XAM7 P35221	Q9NR45
PDB IDs		1H6G 4EHP 4IGG 6UPV 6V2O 6V2P	1WVO
Enriched GO Terms of Interacting Partners?
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