CSNK1E and FAM83D

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CSNK1E	FAM83D
Description		casein kinase 1 epsilon	family with sequence similarity 83 member D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Spindle Cytosol Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Repair Protein Phosphorylation Endocytosis Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Wnt Signaling Pathway Peptidyl-serine Phosphorylation Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Regulation Of Cellular Protein Localization Positive Regulation Of Wnt-mediated Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway	Epithelial To Mesenchymal Transition Signal Transduction Cell Population Proliferation Cell Migration Regulation Of TOR Signaling Regulation Of Protein Catabolic Process Cell Division Metaphase Plate Congression Regulation Of ERK1 And ERK2 Cascade Protein Localization To Mitotic Spindle Positive Regulation Of Cell Cycle G1/S Phase Transition
Pathways		WNT mediated activation of DVL Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Circadian Clock Anchoring of the basal body to the plasma membrane Major pathway of rRNA processing in the nucleolus and cytosol AURKA Activation by TPX2
Drugs		Seliciclib
Diseases
GWAS		Keratoconus ( 31855235)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Huntington's disease progression ( 28642124)
Interacting Genes		55 interacting genes: AKAP9 ANKRD6 APC APP ARHGEF1 ARNTL AXIN1 AXIN2 BBS10 BHLHE41 BID CADM4 CLOCK CRY1 CSNK2B DELEC1 DVL1 DVL2 DVL3 ENTR1 FAM110A FAM110C FAM83D FBP1 FBXO7 FBXW11 GTF3C1 HES1 KAT7 MCC NCOA3 NR1D2 PER1 PER2 PER3 PPP1CA PPP1CC PPP1R14A PPP2R5D PPP2R5E PTPRD RAD54B RBX1 RORA RORC SOCS3 TAOK1 TAZ TNS2 TRAF3 TRIM3 WDCP ZMYND8 ZNF227 ZNF618	5 interacting genes: CSNK1E DYNC1I1 GADD45A GSK3B PRMT1
Entrez ID		1454	81610
HPRD ID		02919	12744
Ensembl ID		ENSG00000213923	ENSG00000101447
Uniprot IDs		P49674 Q5U045	Q9H4H8
PDB IDs		4HNI 4HOK	5E0L 5E0M
Enriched GO Terms of Interacting Partners?
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