CSH1 and PTPN12

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CSH1	PTPN12
Description		chorionic somatomammotropin hormone 1	protein tyrosine phosphatase non-receptor type 12
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endosome Lumen Vesicle	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Growth Hormone Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Response To Nutrient Levels Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Animal Organ Development Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Prolactin receptor signaling Prolactin receptor signaling Growth hormone receptor signaling	SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs			Tiludronic acid
Diseases
GWAS		Height ( 25429064 23563607 31562340)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31015462) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)
Interacting Genes		7 interacting genes: PRLR PSMD9 PTPN12 SGTB SMAD2 SMAD4 SMAD9	57 interacting genes: AATK ABL1 ANP32B APP BAG6 BCAR1 CCDC180 CGA CSH1 CSH2 CSK EFS EGFR ERBB3 ERBB4 FANCC FGFR2 FGFR4 FLT3 FRAT2 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PPP3R2 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SFRP4 SHC1 SMAD1 SMAD5 SORBS2 STX16 STX17 TENM1 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2 ZNF510
Entrez ID		1442	5782
HPRD ID		08350	02513
Ensembl ID		ENSG00000136488	ENSG00000127947
Uniprot IDs		A8K6C2 P0DML2 P0DML3	B4E105 Q05209
PDB IDs		1Z7C	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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