SESN3 and WDR59

Data Source:
BioGRID (pull down)

		SESN3	WDR59
Description		sestrin 3	WD repeat domain 59
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm TORC2 Complex GATOR2 Complex	Lysosomal Membrane GATOR2 Complex
	Molecular Function	Protein Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Leucine Binding	Protein Binding
	Biological Process	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Cellular Response To Leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation	Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation
Pathways		TP53 Regulates Metabolic Genes	Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)	Obesity-related traits ( 23251661) Pancreatic cancer ( 25086665) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Post bronchodilator FEV1/FVC ratio ( 26634245) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Venous thromboembolism ( 32232851)
Interacting Genes		4 interacting genes: MIOS NPRL3 WDR24 WDR59	2 interacting genes: EP300 SESN3
Entrez ID		143686	79726
HPRD ID		09682	13351
Ensembl ID		ENSG00000149212	ENSG00000103091
Uniprot IDs		P58005	Q6PJI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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