ASB7 and HIF1AN

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		ASB7	HIF1AN
Description		ankyrin repeat and SOCS box containing 7	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Notch Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity NF-kappaB Binding Ankyrin Repeat Binding Hypoxia-inducible Factor-asparagine Oxygenase Activity
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction Post-translational Protein Modification	Protein Phosphopantetheinylation Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Vasculogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases
GWAS		Anti-drug antibodies in autoimmune disease (time to event) ( 33125391) Chin dimples ( 27182965) Chronotype ( 30696823) Lower body strength ( 27325353) Morning person ( 30696823) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 28073927) Response to taxane treatment (placlitaxel) ( 23006423) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Body mass index ( 28892062 25673413) Brain morphology (MOSTest) ( 32665545) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303)
Interacting Genes		6 interacting genes: ATF4 CCDC136 HIF1AN HMBOX1 PSRC1 ZFAND2B	19 interacting genes: ANKK1 ANKRD12 ANKRD37 ANKRD50 ASB13 ASB4 ASB7 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		140460	55662
HPRD ID		10674	09426
Ensembl ID		ENSG00000183475	ENSG00000166135
Uniprot IDs		A0A024RC94 A0A024RCD9 Q9H672	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6 6RUJ
Enriched GO Terms of Interacting Partners?
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