CREM and CSNK1A1

Data Source:
HPRD (in vitro, in vivo)

		CREM	CSNK1A1
Description		cAMP responsive element modulator	casein kinase 1 alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm ATF4-CREB1 Transcription Factor Complex	Condensed Chromosome Kinetochore Nucleus Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Keratin Filament
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Fatty Acid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Retinoic Acid Receptor Signaling Pathway Rhythmic Process	Protein Phosphorylation Golgi Organization Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of GTP Binding Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly
Pathways			Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO
Drugs			Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		45 interacting genes: ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX	48 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CRBN CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 UVRAG YWHAQ YWHAZ ZRANB1
Entrez ID		1390	1452
HPRD ID		00444	02739
Ensembl ID		ENSG00000095794	ENSG00000113712
Uniprot IDs		Q03060	B4DER9 P48729 Q6PJ06
PDB IDs			5FQD 6GZD
Enriched GO Terms of Interacting Partners?
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