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CSNK1A1 and AXIN1
Data Source:
HPRD
(in vitro, in vivo)
CSNK1A1
AXIN1
Description
casein kinase 1 alpha 1
axin 1
Image
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Nucleus
Cytoplasm
Centrosome
Cytosol
MRNA Cleavage And Polyadenylation Specificity Factor Complex
Cilium
Membrane
Nuclear Speck
Beta-catenin Destruction Complex
Ciliary Basal Body
Keratin Filament
Nucleus
Cytoplasm
Cytosol
Lateral Plasma Membrane
Beta-catenin Destruction Complex
Cytoplasmic Vesicle
Perinuclear Region Of Cytoplasm
Cell Periphery
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
SMAD Binding
Molecular Adaptor Activity
Armadillo Repeat Domain Binding
I-SMAD Binding
Biological Process
Protein Phosphorylation
Golgi Organization
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Wnt Signaling Pathway
Peptidyl-serine Phosphorylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Intermediate Filament Cytoskeleton Organization
Cell Division
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of GTP Binding
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Multicellular Organism Development
Positive Regulation Of Peptidyl-threonine Phosphorylation
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Activation Of Protein Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Protein-containing Complex Assembly
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Positive Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Activation of SMO
Activation of SMO
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
TCF dependent signaling in response to WNT
Degradation of AXIN
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ub-specific processing proteases
RUNX1 regulates estrogen receptor mediated transcription
RUNX1 regulates transcription of genes involved in WNT signaling
Estrogen-dependent gene expression
Drugs
Fostamatinib
1,4-Dithiothreitol
Diseases
Hepatocellular carcinoma
Caudal duplication anomaly
GWAS
Carotid intima media thickness x smoking interaction (
32117412
)
Chronic obstructive pulmonary disease (
30804561
)
Esophageal cancer (
21642993
)
Adult body size (
32376654
)
Body mass index (
25673413
)
Bone mineral density (spine) (
26733130
)
Femoral neck bone mineral density (
29499414
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Lumbar spine bone mineral density (
29499414
22504420
)
Lumbar spine bone mineral density (integral) (
27476799
)
Lumbar spine bone mineral density (trabecular) (
27476799
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular hemoglobin concentration (
32888494
27863252
)
Mean corpuscular volume (
32888494
27863252
)
Red blood cell count (
27863252
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Waist circumference (
31928498
)
Interacting Genes
48 interacting genes:
ACTB
ADAP1
AP3B1
AP3B2
APC
AXIN1
BID
CDC25A
CHRM3
CRBN
CREM
CTNNB1
EIF2B5
ERF
FADD
GLI3
GNB2
HMGB1
HMGB2
HNRNPC
HSPA4
KPNA2
KPNB1
LGALS3
MAPT
MDM4
NFATC3
OCLN
PDE4D
PHLPP1
PPP1CC
PPP1R14A
PPP2R5A
PSEN2
PTEN
RCC1
SLC18A2
SNCA
SQSTM1
SYT9
TGFBR1
TIAM1
TNFRSF1B
TP53
UVRAG
YWHAQ
YWHAZ
ZRANB1
83 interacting genes:
AMER1
ANP32A
APC
BTRC
CALCOCO2
CARD9
CARM1
CCDC57
CDCA7L
CRMP1
CSNK1A1
CSNK1E
CTNNB1
DAB2
DIXDC1
DVL1
DVL2
DVL3
EEF1A1
ENTR1
ETV6
GAK
GMCL1
GNAS
GOLGA2
GSK3B
HOMEZ
JUP
KRT40
KRTAP10-3
KRTAP4-12
KRTAP4-2
LHX4
LHX8
LMO2
LRP5
LRP6
MAP3K4
MDFI
MEOX2
MID2
MTUS2
MYC
MYOT
NBR1
NCK2
NUTM1
PIAS1
PML
PPP2CA
PPP2CB
PPP2R5B
PPP2R5C
PRMT1
PSTPIP1
RNF111
RUNX2
SCYL1
SENP2
SH3GL1
SIAH1
SMAD2
SMAD3
SMAD7
SMURF1
SMURF2
STX11
SUMO1
SUMO1P1
TFIP11
TP53
TP53BP2
TRAF2
TRIM15
TRIM27
TRIM37
TRIM42
TRIP6
TSGA10
USP7
UTP14A
ZBTB26
ZFYVE19
Entrez ID
1452
8312
HPRD ID
02739
04819
Ensembl ID
ENSG00000113712
ENSG00000103126
Uniprot IDs
B4DER9
P48729
Q6PJ06
A0A0S2Z4R0
A0A0S2Z4S3
O15169
PDB IDs
5FQD
6GZD
1DK8
1EMU
1O9U
3ZDI
4B7T
4NM0
4NM3
4NM5
4NM7
4NU1
5WZZ
6JCK
Enriched GO Terms of Interacting Partners
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