WNK4 and SLC12A3

Data Source:
HPRD (in vivo)

		WNK4	SLC12A3
Description		WNK lysine deficient protein kinase 4	solute carrier family 12 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity
	Biological Process	Protein Phosphorylation Ion Transport Chloride Transport Protein Localization Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Regulation Of Cellular Process Ion Homeostasis Renal Sodium Ion Absorption Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Stimuli-sensing channels	Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)
Drugs			Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) Phoneme awareness ( 30741946)
Interacting Genes		11 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 KLHL2 KLHL3 NEDD4L SLC12A3 STK39	2 interacting genes: PDIA3 WNK4
Entrez ID		65266	6559
HPRD ID		03505	02984
Ensembl ID		ENSG00000126562	ENSG00000070915
Uniprot IDs		Q96J92	J3QSS1 P55017
PDB IDs		2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?
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