CPE and PMCH

Data Source:
HPRD (in vivo)

		CPE	PMCH
Description		carboxypeptidase E	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Extracellular Exosome	Extracellular Region Nucleus Synapse
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Peptide Metabolic Process Neuropeptide Signaling Pathway Wnt Signaling Pathway Protein Processing Protein Localization To Membrane	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Insulin human Insulin pork
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		1363	5367
HPRD ID		00272	01459
Ensembl ID		ENSG00000109472	ENSG00000183395
Uniprot IDs		A0A384N679 P16870	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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