CAMK2B and ACOT7

Data Source:
BioGRID (two hybrid)

		CAMK2B	ACOT7
Description		calcium/calmodulin dependent protein kinase II beta	acyl-CoA thioesterase 7
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection Synapse	Nucleoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Actin Binding Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	Fatty-acyl-CoA Binding Protein Binding Palmitoyl-CoA Hydrolase Activity Long-chain Fatty Acyl-CoA Binding Protein Homodimerization Activity Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Protein Autophosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Regulation Of Cellular Response To Heat Regulation Of Neuron Migration	Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Coenzyme A Biosynthetic Process Medium-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty-acyl-CoA Catabolic Process Medium-chain Fatty Acid Biosynthetic Process Palmitic Acid Biosynthetic Process
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Mitochondrial Fatty Acid Beta-Oxidation
Drugs		[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile Fostamatinib
Diseases
GWAS		Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Intracranial aneurysm ( 29531279) Metabolic syndrome ( 22399527) Osteoarthritis (hip) ( 23989986) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Metabolite levels ( 31628463) QT interval ( 19305408)
Interacting Genes		56 interacting genes: ACOT7 ACTN4 AP5B1 ARSA ATXN1 CAMK2A CAMK2D CAMK2G CAMK2N2 CCM2L CDC37 COL4A3 DUS1L ETS1 FAM171A2 GAPDH GRIN2A GRIN2B ITPKA KRT86 KRTAP1-1 KRTAP10-11 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-2 KRTAP6-3 MAD2L2 MED18 MEOX2 MGAT5B MORF4L1 MORF4L2 MRPL11 MVP PHKB PLCB3 PNKP POLR3C POP5 RAP2B RBFOX2 RBPMS RNF4 RPL11 RXRG SEMA4G SMYD3 SPRYD7 THRB TNPO2 TNPO3 TTC5 YWHAB ZBTB32 ZMYM5	24 interacting genes: ACOT12 ATXN1 ATXN1L BAG4 CAMK2B CDC42 CRYAB DAZAP2 DLC1 ENKD1 LMNA MAGEA3 MAGEA6 NCOA5 POT1 POU6F1 SPATC1L TERF1 THAP1 TINF2 UBQLN1 UBQLN2 UBXN1 ZNF438
Entrez ID		816	11332
HPRD ID		12127	12517
Ensembl ID		ENSG00000058404	ENSG00000097021
Uniprot IDs		A4D2J9 B7Z1Z6 Q13554	O00154
PDB IDs		3BHH	2QQ2
Enriched GO Terms of Interacting Partners?
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