COL1A2 and SHBG

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COL1A2	SHBG
Description		collagen type I alpha 2 chain	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Exosome
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Steroid Binding Androgen Binding Protein Binding
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Blood Pressure Cytokine-mediated Signaling Pathway Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Regulation Of Immune Response Leukocyte Migration Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization
Drugs			Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Osteogenesis imperfecta
GWAS		Aging ( 22773346) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)
Interacting Genes		31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		1278	6462
HPRD ID		00363	01646
Ensembl ID		ENSG00000164692	ENSG00000129214
Uniprot IDs		A0A0S2Z3H5 P08123	B0FWH2 B0FWH8 B4DYU0 I3L145 P04278
PDB IDs		5CTD 5CTI 5CVA 6JEC	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?