SHBG and SEMA3F

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SHBG	SEMA3F
Description		sex hormone binding globulin	semaphorin 3F
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Extracellular Space Integral Component Of Plasma Membrane Glutamatergic Synapse
	Molecular Function	Steroid Binding Androgen Binding Protein Binding	Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process		Neural Crest Cell Migration Axon Guidance Facial Nerve Structural Organization Trigeminal Nerve Structural Organization Nerve Development Branchiomotor Neuron Axon Guidance Positive Regulation Of Cell Migration Ventral Trunk Neural Crest Cell Migration Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Negative Chemotaxis Sympathetic Ganglion Development Semaphorin-plexin Signaling Pathway Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Regulation Of Postsynapse Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways
Drugs		Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)	Age at first birth ( 27089180) Age at first sexual intercourse ( 27089180) Body mass index ( 26426971 29273807) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Glaucoma ( 31959993) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 29785010 31959993) Mean platelet volume ( 32888494) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	7 interacting genes: NRP1 NRP2 SHBG SLC35G2 UBA1 UBC VEGFA
Entrez ID		6462	6405
HPRD ID		01646	03079
Ensembl ID		ENSG00000129214	ENSG00000001617
Uniprot IDs		B0FWH2 B0FWH8 B4DYU0 I3L145 P04278	C9JPG5 Q13275 Q59G50
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
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