COL1A1 and NID1

Data Source:
HPRD (in vitro)

		COL1A1	NID1
Description		collagen type I alpha 1 chain	nidogen 1
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GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Collagen Binding Laminin Binding Laminin-1 Binding Proteoglycan Binding
	Biological Process	Skeletal System Development Ossification Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Blood Coagulation Visual Perception Sensory Perception Of Sound Response To Mechanical Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Development Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Regulation Of Immune Response Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride	Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Glomerular Basement Membrane Development Basement Membrane Organization
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling RUNX2 regulates osteoblast differentiation Collagen chain trimerization	Degradation of the extracellular matrix Degradation of the extracellular matrix Laminin interactions Laminin interactions
Drugs		Collagenase clostridium histolyticum Halofuginone Clove oil Vonicog Alfa Von Willebrand Factor Human	Urokinase
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Infantile cortical hyperostosis; Caffey disease Osteogenesis imperfecta
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Breast cancer ( 17903305) Heel bone mineral density ( 30598549) Response to taxane treatment (docetaxel) ( 23006423)	Cutaneous nevi ( 21478494) Diverticulitis ( 28585551) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Response to levetiracetam in genetic generalized epilepsy ( 32308125) Urate levels in overweight individuals ( 25811787)
Interacting Genes		40 interacting genes: ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 CDC42 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 KEAP1 MAG MATN2 MCPH1 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN UBC VWF	21 interacting genes: APP COL13A1 COL1A1 COL4A1 FBLN1 FBLN2 FGA FGB HSPG2 ITGAV ITGB3 LACRT LAMA1 LAMC1 LAMC2 LGALS3BP PLAU PLXDC1 PRELP PTPRF SKIL
Entrez ID		1277	4811
HPRD ID		00362	00574
Ensembl ID		ENSG00000108821	ENSG00000116962
Uniprot IDs		P02452	P14543
PDB IDs		1Q7D 2LLP 3EJH 3GXE 5CTD 5CTI 5CVA 5CVB 5K31 5OU8 5OU9	1NDX
Enriched GO Terms of Interacting Partners?
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