MAB21L3 and SPRED1

Data Source:
BioGRID (two hybrid)

		MAB21L3	SPRED1
Description		mab-21 like 3	sprouty related EVH1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytosol Plasma Membrane Caveola Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process		MAPK Cascade Inactivation Of MAPK Activity Negative Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Phosphatase Activity Negative Regulation Of Angiogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Vasculogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Deacetylation Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Coffee consumption ( 29367735) Macular thickness ( 30535121)	Bipolar disorder ( 20351715) Birth weight ( 31043758) Cognitive performance (processing speed) ( 31598132) Crohn's disease ( 23128233) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285)
Interacting Genes		28 interacting genes: ABT1 AGGF1 ANKRD36B AP2M1 BEGAIN CT45A1 DVL3 EAF1 EHHADH EMD FAM9B FCHO1 GPATCH2L INO80E KRTAP10-9 KXD1 LBX1 LENG1 LZTS2 MED4 NTAQ1 PHC2 SPG21 SPRED1 STAC3 STK19 ZCCHC10 ZNF165	37 interacting genes: ANKS1A AQP1 BEX2 BLZF1 C2orf68 CCDC185 CDKN1A CREB5 DNAJB11 FAM118B FAM90A1 GLYCTK HEXIM2 HPCAL4 HSF2BP IL16 KIT MAB21L3 MEOX2 NAGK NCALD OSGEP PIH1D2 PPP1CA PPP1R7 PRPF18 RCC1 RIN1 SPG21 SUV39H1 TSC22D1 TTC19 VSNL1 ZNF408 ZNF417 ZNF587 ZNF655
Entrez ID		126868	161742
HPRD ID		08245	11601
Ensembl ID		ENSG00000173212	ENSG00000166068
Uniprot IDs		Q8N8X9	Q7Z699
PDB IDs			3SYX 6V65 6V6F
Enriched GO Terms of Interacting Partners?
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