ZNF440 and MAP4K5

Data Source:
BioGRID (two hybrid)

		ZNF440	MAP4K5
Description		zinc finger protein 440	mitogen-activated protein kinase kinase kinase kinase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Intracellular Signal Transduction
Pathways		Generic Transcription Pathway
Drugs			Fostamatinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) White blood cell count ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cognitive performance ( 20125193) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Red blood cell count ( 32888494)
Interacting Genes		36 interacting genes: CARD10 CCDC136 CCNDBP1 CLK2 CSNK2A1 CYSRT1 FHL5 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 KRTAP5-7 KRTAP5-9 KRTAP9-3 LMNA MAP4K5 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA PAX9 PJA1 STX1A TRAF1 XBP1 ZNF330	13 interacting genes: ABL1 BCR COPS5 CRK CRKL GRB2 HCK NEDD4 SETDB1 SMURF1 TANK TRAF2 ZNF440
Entrez ID		126070	11183
HPRD ID		11718	05374
Ensembl ID		ENSG00000171295	ENSG00000012983
Uniprot IDs		Q8IYI8	B3KWC4 Q9Y4K4
PDB IDs
Enriched GO Terms of Interacting Partners?
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