DCUN1D3 and CUL2

Data Source:
BioGRID (enzymatic study)

		DCUN1D3	CUL2
Description		defective in cullin neddylation 1 domain containing 3	cullin 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Plasma Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Molecular_function Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Response To UV-C Response To Gamma Radiation Regulation Of Cell Cycle Process Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Neddylation Negative Regulation Of Protein Neddylation Positive Regulation Of Protein Neddylation	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways		Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hippocampal sclerosis ( 25188341)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		3 interacting genes: CUL2 CUL3 UBE2M	25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B
Entrez ID		123879	8453
HPRD ID		14660	06786
Ensembl ID		ENSG00000188215	ENSG00000108094
Uniprot IDs		Q8IWE4	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		4GBA	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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