CCR4 and CLASP2

Data Source:
BioGRID (two hybrid)

		CCR4	CLASP2
Description		C-C motif chemokine receptor 4	cytoplasmic linker associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Kinetochore Condensed Chromosome Kinetochore Cytoplasm Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Kinetochore Microtubule Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Plasma Membrane Focal Adhesion Cell Cortex Membrane Cell Leading Edge Ruffle Membrane Basal Cortex Mitotic Spindle
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Dystroglycan Binding Protein Binding Microtubule Binding Microtubule Plus-end Binding
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Microtubule Cytoskeleton Organization Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Microtubule Organizing Center Organization Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Cell Division Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Protein Localization To Plasma Membrane Positive Regulation Of Extracellular Matrix Disassembly Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Mogamulizumab FLX475
Diseases
GWAS		Asthma ( 31959851) Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)	Metabolite levels ( 23823483)
Interacting Genes		37 interacting genes: ATP2A2 B3GAT3 BSG CACNA1H CCKBR CCL17 CCL22 CCL3 CCL5 CDK10 CH25H CLASP2 CLPTM1 CNTNAP1 DHCR24 ERGIC3 FAM234A FXR2 GHITM GRK2 GRK3 NAT14 NDRG2 NSUN2 PKM PRDX1 PTOV1 RTN1 RTN4 SLC12A5 SLC3A2 SLCO4A1 STIMATE SYNGR2 TMEM101 TMEM11 TRARG1	15 interacting genes: ADRB2 AKT1 CCR4 CLIP1 CLIP2 CSNK2A1 ERBB2 FEZ1 FEZ2 MAPRE1 MAPRE2 MARK3 PYGM RBFOX2 SRPK2
Entrez ID		1233	23122
HPRD ID		05324	12054
Ensembl ID		ENSG00000183813	ENSG00000163539
Uniprot IDs		A0N0Q1 P51679	E3W994 E7ERI8 O75122
PDB IDs			3WOY 5NR4
Enriched GO Terms of Interacting Partners?
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