SP7 and TRIM62

Data Source:
BioGRID (two hybrid)

		SP7	TRIM62
Description		Sp7 transcription factor	tripartite motif containing 62
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Positive Regulation Of Stem Cell Differentiation	Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell
Pathways		RUNX2 regulates osteoblast differentiation	Interferon gamma signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		6 interacting genes: CBL CBLB FAM124B GAS8 QARS1 TRIM62	19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25
Entrez ID		121340	55223
HPRD ID		05971	07697
Ensembl ID		ENSG00000170374	ENSG00000116525
Uniprot IDs		A0A024RAY8 Q8TDD2	Q9BVG3
PDB IDs
Enriched GO Terms of Interacting Partners?
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