LRRK2 and ESRRG

LRRK2

ESRRG

Description leucine rich repeat kinase 2 estrogen related receptor gamma
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adventurousness ( 30643258)
  • Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065)
  • Adverse response to drug ( 30420678)
  • Alcohol consumption ( 23743675)
  • Breast cancer ( 29059683)
  • Cardiac hypertrophy ( 21348951)
  • Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761)
  • Depressive symptom (anhedonia) (ordinal trait) ( 31530331)
  • Dialysis-related mortality ( 21546767)
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
  • Energy expenditure (24h) ( 28476931)
  • General cognitive ability ( 29844566)
  • General risk tolerance (MTAG) ( 30643258)
  • Gut microbiota relative abundance (Ruminococcus belonging to family Erysipelotrichaceae) ( 33208821)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Intelligence (MTAG) ( 29326435)
  • Intracranial aneurysm ( 29531279)
  • Major depressive disorder ( 23377640)
  • Mean arterial pressure (alcohol consumption interaction) ( 24376456)
  • Nicotine dependence and major depression (severity of comorbidity) ( 30287806)
  • Optic nerve measurement (cup area) ( 20395239)
  • Photic sneeze reflex ( 27182965)
  • Post bronchodilator FEV1 ( 26634245)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Refractive error ( 32231278)
  • Sleep duration ( 25469926)
  • Smoking status (ever vs never smokers) ( 30643258)
  • Tea consumption ( 31046077)
  • Weight ( 28552196)
Interacting Genes 144 interacting genes: ABLIM1 ACTB AFF4 AHCYL1 AHDC1 AKT1 ANKS4B APEX2 APP ARFGAP1 ARHGEF7 AURKB BAG1 BAG2 BAG3 C18orf25 C1orf87 CAMK1D CBLB CCDC43 CDC42EP3 CDKL3 CETN3 CHGB CRMP1 CUEDC1 CXCL11 CYREN DBF4B DDIT4 DIDO1 DUX3 DVL1 DVL2 DVL3 DYRK2 E2F4 ECHS1 EIF4EBP1 ENKUR ESRRG FAM184A FAM47B FAM90A1 FANCM FCHSD1 GTSF1 HIF1A HSPD1 ITGB3BP JHY KCTD18 KDM4D KLC2 L3MBTL3 LARP4 LARP7 LATS1 LGALS8 LINC01139 LRP6 MAP1B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPT MATK MBP MLLT3 MRGBP MRPL19 MRPL28 MTA1 MYL9 NCBP3 NDUFAF7 NEK1 NSL1 PADI4 PDCL PHF20L1 PIK3CB PIK3R1 PLK1 POLR2M POU5F1 PPP1R8 PRKCZ PSME3IP1 PTPN23 RAB11FIP2 RAD51AP1 RALYL RAPGEF4 RASL11B RBIS RHBDD1 RIPK2 RIT1 RPAP3 RPS6KB2 SCEL SERF1A SH3GL2 SH3GL3 SKA3 SMTNL2 SPATS2 SQSTM1 STAC STK24 STK25 STK3 STK40 STN1 STRBP STUB1 SUPT4H1 SYNJ1 TAOK3 TAS2R60 TBC1D22B TCEA2 TCP10L TGIF2LX TRAF2 TTC27 TTLL1 TUBA1A UBXN10 UFD1 UQCRB USP39 VASH2 VGLL4 VN1R1 WSB1 WT1-AS XIRP2 ZAP70 ZFAND5 ZMYM5 ZRANB2 58 interacting genes: ADCY4 APP ARHGEF15 ATM BPHL C22orf23 CALM1 CAMK2G CCDC33 DAXX DEUP1 DUT EBP EFHC2 ESRRA ESRRB EXOSC7 FAM107A FAM9A FASTK HGS HIF1A KIFC3 LRRK2 MCC MEOX2 MFHAS1 MRM1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PAX6 PNRC1 PNRC2 POMC PPARGC1A PPARGC1B PROX1 PSMC5 RBIS REL RINT1 SHTN1 SNIP1 SP1 SRA1 SRPK1 SUMO1P1 TLE1 TNNI1 TNNI2 TRERF1 TULP3 UBL7 VAX1 ZNF438
Entrez ID 120892 2104
HPRD ID 10613 04274
Ensembl ID ENSG00000188906 ENSG00000196482
Uniprot IDs Q17RV3 Q5S007 B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs 2ZEJ 3D6T 5MY9 5MYC 6DLO 6DLP 6OJE 6OJF 6VNO 6VP6 6VP7 6XR4 1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67 6K3N 6KNR
Enriched GO Terms of Interacting Partners?
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