CKM and MYOC

Data Source:
HPRD (two hybrid)

		CKM	MYOC
Description		creatine kinase, M-type	myocilin
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Creatine metabolism
Drugs		Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid D-arginine Phosphocreatine
Diseases			Primary open angle glaucoma
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Creatine kinase levels in statin users ( 25214527) Intelligence (MTAG) ( 29326435)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Intake of total sugars ( 31005972)
Interacting Genes		14 interacting genes: ASB9 CBLC CKB CKMT1A CKMT1B FHL2 HSPB2 MYOC MYOM2 NOS1AP TRIM54 TRIM55 TRIM63 YWHAQ	41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		1158	4653
HPRD ID		00426	03387
Ensembl ID		ENSG00000104879	ENSG00000034971
Uniprot IDs		B2R892 P06732	A0A0S2Z421 Q99972
PDB IDs		1I0E	4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF
Enriched GO Terms of Interacting Partners?
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