MYOC and ITGA7

Data Source:
HPRD (two hybrid)

		MYOC	ITGA7
Description		myocilin	integrin subunit alpha 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Vesicle Node Of Ranvier Collagen-containing Extracellular Matrix Extracellular Exosome	Plasma Membrane Integrin Complex Cell Surface
	Molecular Function	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation
Pathways			Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans
Drugs
Diseases		Primary open angle glaucoma	Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Glaucoma ( 30104761) Intake of total sugars ( 31005972)	Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)
Interacting Genes		41 interacting genes: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 SGTA TGFBR1 TIMP1 TKT TNFRSF1A	4 interacting genes: CHRNA1 FHL2 FHL3 MYOC
Entrez ID		4653	3679
HPRD ID		03387	02761
Ensembl ID		ENSG00000034971	ENSG00000135424
Uniprot IDs		A0A0S2Z421 Q99972	Q13683 Q4LE35
PDB IDs		4WXQ 4WXS 4WXU 6OU0 6OU1 6OU2 6OU3 6PKD 6PKE 6PKF
Enriched GO Terms of Interacting Partners?
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