FBXO17 and CDCA8

Data Source:
BioGRID (two hybrid)

		FBXO17	CDCA8
Description		F-box protein 17	cell division cycle associated 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Glycoprotein Catabolic Process Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		22 interacting genes: ADAMTSL4 ADRB2 CBY2 CDCA8 DZIP3 EIF4H JRK KPRP KRT75 KRTAP13-2 LASP1 OAS2 PTPN21 RAB11FIP2 RUNX1 SAXO1 SAXO2 SKP1 USP54 ZNF213 ZNF829 ZSCAN9	26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		115290	55143
HPRD ID		16436	13017
Ensembl ID		ENSG00000269190	ENSG00000134690
Uniprot IDs		Q96EF6	Q53HL2
PDB IDs			2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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