EFHC1 and SPATA2

Data Source:
BioGRID (two hybrid)

		EFHC1	SPATA2
Description		EF-hand domain containing 1	spermatogenesis associated 2
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Centrosome Axoneme Neuronal Cell Body Mitotic Spindle	Fibrillar Center Nucleoplasm Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Protein C-terminus Binding Alpha-tubulin Binding	Protein Binding Signaling Receptor Complex Adaptor Activity Protein-containing Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Regulation Of Cell Division Cilium-dependent Cell Motility	Spermatogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inflammatory Response Regulation Of Necroptotic Process Necroptotic Process Protein K63-linked Deubiquitination Seminiferous Tubule Development Protein Linear Deubiquitination
Pathways
Drugs
Diseases		Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)	Coronary artery disease ( 29212778) Gut microbiota (beta diversity) ( 27723756) Psoriasis ( 20953189 25574825 18364390)
Interacting Genes		67 interacting genes: C11orf45 C20orf85 CACNA1E CALCOCO2 CCDC130 CFAP161 CHCHD3 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN ZBED1	22 interacting genes: ANKRD11 APP ATP6V1H C2CD6 CCDC102B CEP72 DUT EFHC1 GOLGA2 GPANK1 KAT5 KIFC3 LENG1 MAD1L1 OTULIN PTPN6 RNF31 TBC1D22B TNIP1 TRAF2 TRIM27 ZNF835
Entrez ID		114327	9825
HPRD ID		10583	09636
Ensembl ID		ENSG00000096093	ENSG00000158480
Uniprot IDs		B2CKC5 Q5JVL4	A8K0S9 B4DID4 Q9UM82
PDB IDs			5LJM 5LJN
Enriched GO Terms of Interacting Partners?
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