CHRNB4 and CHRNA2

Data Source:
HPRD (in vivo, in vitro)

		CHRNB4	CHRNA2
Description		cholinergic receptor nicotinic beta 4 subunit	cholinergic receptor nicotinic alpha 2 subunit
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding	Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine	Nicotine Butabarbital Carbamoylcholine Metocurine iodide Fluoxetine Gallamine triethiodide Dextromethorphan Cisatracurium Mecamylamine Procaine Rocuronium Atracurium besylate Ethanol Doxacurium Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine Hexamethonium
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 33020668) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 31209380) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656)
Interacting Genes		6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 MEOX2 UBQLN1	2 interacting genes: CHRNB2 CHRNB4
Entrez ID		1143	1135
HPRD ID		00337	00332
Ensembl ID		ENSG00000117971	ENSG00000120903
Uniprot IDs		P30926	Q15822
PDB IDs		2ASG 6PV7 6PV8	5FJV
Enriched GO Terms of Interacting Partners?
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