TRIM9 and VASP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIM9	VASP
Description		tripartite motif containing 9	vasodilator stimulated phosphoprotein
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Synaptic Vesicle Dendrite Presynaptic Cytosol	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome
	Molecular Function	SNARE Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Psychosis (atypical) ( 24132900) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Urate levels (BMI interaction) ( 25811787)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		32 interacting genes: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 FAM124B FAM90A1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID NTAQ1 PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 UTP25 VASP	44 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CDC42 CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		114088	7408
HPRD ID		05947	03415
Ensembl ID		ENSG00000100505	ENSG00000125753
Uniprot IDs		Q9C026	A0A024R0V4 P50552
PDB IDs		2DB8	1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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