U2AF2 and INO80B

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		U2AF2	INO80B
Description		U2 small nuclear RNA auxiliary factor 2	INO80 complex subunit B
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GO Annotations	Cellular Component	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF Complex	Nucleoplasm Nucleolus Ino80 Complex
	Molecular Function	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding	Protein Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	DNA Repair DNA Recombination Protein Deubiquitination ATP-dependent Chromatin Remodeling
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Menopause (age at onset) ( 26414677)
Interacting Genes		75 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CDC42 CHERP CHIC2 CPSF7 DACH1 DDX39B DDX6 DPPA2 DVL2 EPB41 FUBP1 GEMIN2 GLIS2 HLA-DMA HMBOX1 IL7R INO80B KHDC4 KHDRBS3 LURAP1 MAP1B MRPL15 NKAPD1 OTUB2 PHF5A PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM11 RBM39 RBM4 RBMY1F RBMY1J SAP30BP SCAF11 SF1 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SRSF3 STAC3 SUGP1 SUMO2 TCERG1 TCF23 THAP1 TLE5 TOP1 U2AF1 U2AF1L5 WT1 ZNF107 ZNF526 ZNF57 ZNF71 ZNF835 ZRSR2 ZRSR2P1	64 interacting genes: ABI2 BANP BHLHB9 BOLL CARD9 CAVIN1 CCDC85B CD81 CDR2L CEP70 CSNK2B CYSRT1 DPPA4 DVL3 E2F6 FLACC1 GOLGA6L9 HMBOX1 HMGXB4 HOMEZ HOXA1 HSF2BP IGFBP2 KCTD7 KRT34 KRT40 KRTAP10-8 KRTAP12-2 KRTAP19-1 KRTAP6-2 LHX4 LIMS1 LZTS2 MID2 MKRN3 MORN3 MTUS2 MYLIP NBPF19 NOTCH2NLA PICK1 PIP4K2B PLAGL2 PNMA1 PNMA2 RBM39 RIMBP3C SOX13 SSX2IP STAC3 THAP1 TLE5 TNS2 TRAF2 TRIB3 TRIM27 TSPYL2 U2AF2 UIMC1 USH1G YAF2 ZNF526 ZNF552 ZRANB1
Entrez ID		11338	83444
HPRD ID		01872	17110
Ensembl ID		ENSG00000063244	ENSG00000115274
Uniprot IDs		P26368	Q9C086
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H 6TR0 6XLV 6XLW 6XLX	6HTS
Enriched GO Terms of Interacting Partners?
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